The IS6 family, a clinically important group of insertion sequences including IS26

Insertion Sequence IS26 Reorganizes Plasmids in Clinically Isolated Multidrug-Resistant Bacteria by Replicative Transposition

UNLABELLED Carbapenemase-producing Enterobacteriaceae (CPE), which are resistant to most or all known antibiotics, constitute a global threat to public health. Transposable elements are often associated with antibiotic resistance determinants, suggesting a role in the emergence of resistance. One insertion sequence, IS26, is frequently associated with resistance determinants, but its role remai...

A family of insertion sequences that impacts integrons by specific targeting of gene cassette recombination sites, the IS1111-attC Group.

Integrons facilitate the evolution of complex phenotypes by physical and transcriptional linkage of genes. They can be categorized as chromosomal integrons (CIs) or mobile resistance integrons (MRIs). The significance of MRIs for the problem of multiple antibiotic resistance is well established. CIs are more widespread, but their only demonstrated significance is as a reservoir of gene cassette...

IS26-Mediated Precise Excision of the IS26-aphA1a Translocatable Unit

UNLABELLED We recently showed that, in the absence of RecA-dependent homologous recombination, the Tnp26 transposase catalyzes cointegrate formation via a conservative reaction between two preexisting IS26, and this is strongly preferred over replicative transposition to a new site. Here, the reverse reaction was investigated by assaying for precise excision of the central region together with ...

IS200 is not a member of the IS600 family of insertion sequences.

IS200 is an insertion sequence present in all Salmonella species except S. agona (1, 2). The element is absent from all other Enterobacteriaceae, with the exception of some strains of Shigella flexneri and Shigella sonnei (2). It had been hypothesized that the first mutation characterized as an IS200 insertion, hisD984: :IS200 (1, 3) might actually be a deletion mutant of the Shigella insertion...

Clinically important drug interactions.